Protocols of IVF/ICSI in Poor Responders

Launched by CAIRO UNIVERSITY · Apr 18, 2020

Keywords

ClinConnect Summary

The two groups of poor responders are randomized into either; a minimal dose stimulation protocol involving letrozole, recombinant FSH and GnRH antagonist versus a microflare conventional protocol with OCP, GnRH agonist and high dose recombinant FSH, in their IVF/ICSI cycles, primary outcome will be the number of oocytes retrieved.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• 1- More than 1 year of infertility 2 - Poor ovarian responder according to the Bologna criteria:
• • 1. Advanced maternal age
• • 2. Previous poor ovarian response
• • 3. Abnormal tests of ovarian reserve (AFC \< 5-7, AMH \<0.5-1.1 ng/ml)
• Exclusion Criteria:
• • 1. Age \> 43 years
• • 2. baseline FSH \>15 mIU/ml
• • 3. Previous ovarian surgery
• • 4. Ovarian endometrioma
• • 5. Uterine anomaly or myoma
• • 6. Any medical disorder
• • 7. Any hormonal disorder eg. hyperprolactinemia
• • 8. BMI \> 30 kg/m2
• • 9. Severe male factor