Role of Vitamin C in Cardiac Vasoplegia After Cardiopulmonary Bypass

Launched by CAIRO UNIVERSITY · Aug 17, 2020

Keywords

ClinConnect Summary

Background and Rationale:

Cardiac vasoplegia is a known phenomenon after cardiopulmonary bypass (CPB) occurring in up to 44% of patients. Severe forms of such condition refractory to vasopressors are associated with poor outcomes. New agents e.g. ascorbic acid that can alter the systemic vascular resistance in cardiac vasoplegia have been suggested as an attempt to avoid or at least reduce the use of IV vasopressors and their induced systemic hypo-perfusion.

Objectives :

* Primary objective: to study the effect of vitamin C administration on the amount of noradrenaline given post-operati...

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Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing cardiac surgeries with CPB having risk factors for cardiac vasoplegia like diabetes mellitus and chronic renal failure.
• Exclusion Criteria:
• • Patients who undergo surgeries without cardiopulmonary bypass (off-pump)
• • Patients undergoing surgeries for congenital cardiac disease
• • Patients performing heart transplantation and combined cardiac surgeries
• • Patients with low pre-operative left ventricular ejection fraction (LVEF)
• • Patients refusing to participate
• • Patients who receive vasopressors other than noradrenaline