Prediction of Arterial Lactate and Blood Gas Values Through the Analysis of Central Venous Blood

Launched by CENTRE HOSPITALIER RÉGIONAL D'ORLÉANS · Aug 29, 2020

Keywords

ClinConnect Summary

Mathematical models for predicting arterial blood gas and arterial lactate have recently be published (PMID 27543529; see the citations section). The aim of the study is to externally validate these models in a multicenter (11 centres in France) cohort of intensive care unit patients suffering from acute circulatory failure. For the peru pose of the study, patients will undergo concomitent central venous/arterial blood sampling from 1 to 4 times during their intensive cafe unit stay. Clinical characteristics of the patients and central venous blood gas and lactate values will be used to pre...

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Eligibility criteria

• Inclusion Criteria:
• • age\>18 years
• • patient admitted in a intensive care unit
• • patient already carrying an indwelling arterial catheter and a superior vena cava central catheter
• • patient presenting an acute circulatory failure defined by the presence of at least two of the following items: a) Persistent hypotension (systolic arterial blood pressure \< 90 mm Hg or mean arterial pressure \< 65 mm Hg) or need for continuous intravenous vasopressor treatment (at any dose). b) Presence of at least one of the following signs of hypoperfusionfusion :Change in mental status ; Skin mottling ; Oliguria (Urine output \<0.5 ml/kg body weight for at least one hour); Arterial lactate \> 2 mmol/l or peripheral venous lactate \> 3.2 mmol/l; ScvO2 \<70%.
• • Routine medical management requires central venous blood sampling for ScvO2 measurement and arterial blood sampling for gazometry.
• Exclusion Criteria:
• • Opposition to participation in the study
• • Impossibility to take a concomitant arterial and venous gazometric sample.
• • Patient treated with ECMO (extracorporeal membrane,oxygrnation), intermittent dialysis or continuous dialysis during sampling
• • Patient hospitalized without consent and/or deprived of liberty by court decision.