Inducible Laryngeal Obstruction in Severe Asthma in Severe Asthma

Launched by HAUKELAND UNIVERSITY HOSPITAL · Oct 13, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a condition called Inducible Laryngeal Obstruction (ILO) in people with severe asthma. ILO can make it hard to breathe when the vocal cords in the throat close unexpectedly. The first part of the study will compare people with asthma to those without asthma to see how often ILO and other related health issues occur. The second part will follow participants for one year to track their symptoms and asthma outcomes over time.

To be eligible for this trial, participants need to be between the ages of 18 and 70 and have severe asthma or mild to moderate asthma that is well-controlled. There will also be a group of control participants without asthma who are matched by age and gender. It's important to note that people with certain conditions, like serious neurological diseases or a history of severe asthma attacks requiring hospitalization, cannot participate. If you join the trial, you can expect to have your symptoms monitored and assessed over the year, helping researchers understand more about the relationship between asthma and ILO.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Patients with severe asthma (GINA 5)
• • Patients with mild-moderate well-treated asthma (GINA step 1-4)
• • Agroup of age- and gender matched control subjects without asthma also aged 18- 70.
• • The patients must have had a stable disease the last one month before performing the CLE-test
• Exclusion Criteria:
• • No have underlying neurologic disease.
• • No known cancer in the lung-head-neck
• • No known vocal cord pathology.
• • No history of life-threatening asthma required hospitalization.