Recognizing Pain Intensity in Alzheimer's Disease

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE · Oct 29, 2020

Keywords

ClinConnect Summary

It will therefore be a question of inducing experimental pain in patients with Alzheimer's disease, in the early stages of the disease and to check whether pain-related changes in the autonomic nervous system via the Nociception Level index (NoL® system) differ from a control group of subjects matched in age, gender and education level. To induce pain, the investigators will use the "cold pressor test" technique, which consists of leaving the arm immersed in ice water for as long as the pain is bearable. The investigators will also record before, during and after the immersion, the variatio...

Gender

ALL

Eligibility criteria

• Inclusion Criteria for patients with alzheimer's disease :
• • Diagnosis of the disease by a hospital doctor after an etiological assessment including at least a cerebral MRI, a neuropsychological assessment and, if possible, dementia markers in the cerebrospinal fluid.
• • Mini Mental State Score \> 23
• Inclusion Criteria for control subject :
• • - Matching by age (± 5 years), gender, and grade level
• Exclusion Criteria for 2 groups :
• • presence of pain,
• • Presence of mood and/or psychiatric disorders (HAD A ou A scores \>7).
• • Presence of cardiovascular risk factors and beta-blocker and/or calcium channel blocker therapy.
• • Patients under guardianship or curatorship