Chlorpheniramine Maleate Nasal Spray for Chronic Rhinitis

Launched by LARKIN COMMUNITY HOSPITAL · Mar 9, 2021

Keywords

ClinConnect Summary

Allergic rhinitis is defined as the symptoms of sneezing, nasal itching, airflow obstruction and, mostly, clear nasal discharge caused by IgE-mediated reactions against inhaled allergens and involving mucosal inflammation driven by T cells (Th2) auxiliary type 2. pollens and molds, as well as allergens from perennial interiors, such as dust mites, pets, pests and some molds. The pattern of dominant allergens depends on the geographic region and degree of urbanization, but the general prevalence of sensitization to allergens does not vary among census districts in the United States.2 Sensiti...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. No oral steroids
• • 2. No oral antihistamine
• • 3. No Nafasoline If the patient needs rescue treatment, he will go to the intervention arm with chlorpheniramine or with the combination of chlorpheniramine and fluticasone. If a participant experienced a severe acute nasal block, the investigator could authorize the use of a short course of oxymetazoline spray for a maximum of 3 days and a maximum total of 1 day during the treatment period. Oxymetazoline should not be used within 24 hours of a scheduled visit during the study.
• Exclusion Criteria:
• • 1. Large (grade 3) polyps, indicating severe nasal obstruction
• • 2. Surgical treatment for nasal polyps during the last 3 months
• • 3. Cystic fibrosis
• • 4. Purulent nasal infection
• • 5. Allergic rhinitis
• • 6. Any disease likely to interfere with the study parameters or which gave evidence of any serious or unstable concurrent disease or psychological disorder