Early Nutritional Intervention in NPC Patients Undergoing Concurrent Chemoradiotherapy

Launched by GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL · Mar 19, 2021

Keywords

ClinConnect Summary

Concurrent chemoradiotherapy is the standard treatment for locally advanced nasopharyngeal carcinoma (NPC). During chemoradiotherapy, malnutrition is present in 44-88% patients which is associated with adverse clinical outcomes. Although patients receive conventional nutritional intervention recommended by The European Society for Clinical Nutrition and Metabolism guidelines, there are still 35% NPC patients suffering from malnutrition during chemoradiotherapy.

Recent studies have shown that early nutritional intervention before radiotherapy reduced the prevalence of malnutrition. However,...

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Eligibility criteria

• Inclusion Criteria:
• • Pathologically confirmed nasopharyngeal carcinoma (NPC).
• • The clinical stage of NPC is T1-4 N1-3 M0 (AJCC 7th edition).
• • Planned to receive concurrent chemoradiotherapy with intensity-modulated radiation therapy (IMRT).
• • Age ≥ 18 years and \< 75 years.
• • Performance status (PS) score 0-1.
• • NRS2002\<3 .
• • Blood regular test should be satisfied the following conditions: white blood cell count ≥3.5×109/L， Neutrophil count ≥1.5×109/L，platelet count ≥100×109/L，hemoglobin ≥10g/L
• • Liver and kidney functions test should be satisfied the following conditions: aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) \< 2.5 times the upper limit of normal value, bilirubin \< 1.2 times the upper limit of normal value, creatinine \< 1.2 times the upper limit of normal value, and alkaline phosphatase \< 5 times the upper limit of normal value.
• • Could complete required oral nutrition, questionnaire survey and follow-up.
• • Signed informed consent voluntarily.
• Exclusion Criteria:
• • Had a history of head and neck radiotherapy.
• • Known allergic reaction to any component of ONS, or severe allergic constitution.
• • With any unstable systemic disease (such as uncontrolled infectious diseases, uncontrolled hypertension, uncontrolled metabolic diseases and so on).
• • Serious cardiovascular diseases in 6 months (such as Congestive heart failure and myocardial infarction).
• • Pregnancy and lactation.
• • Other conditions that the investigators consider as inappropriate for enrolling into this study.
• • Has a history of malignant tumors in 5 years, except for tumors that have been cured only by surgery and with a disease free survival for five years, cured basal cell carcinoma of skin and cured carcinoma in situ of the cervix.