Healing of Apical periodontitis-the Effect of Diabetes Mellitus and Tobacco Smoking
Launched by ROMANA PERŠIĆ BUKMIR · Mar 19, 2021
Trial Information
Current as of June 03, 2025
Completed
Keywords
ClinConnect Summary
Apical periodontitis is an inflammatory process located around the apex of the root. It is mainly caused by a microbial infection of the pulp space. Diabetes mellitus and tobacco smoking are modulating factors that may influence the healing of apical periodontitis. Present studies have disclosed an association between smoking and apical periodontitis and diabetes mellitus and apical periodontitis. The aim of this study is to compare the healing of periapical bone in smokers and non-smokers and patients with diabetes mellitus type 2 and healthy participants. The hypothesis of this study is t...
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- • 1. Influence of smoking habit on apical periodontitis healing after non-surgical endodontic treatment
- • Smoker group- everyday cigarette smoking habit, older than 18 years
- • Control group-healthy non-smoker patients, older than 18 years, paired with smoker group according to age and sex
- • 2. Influence of diabetes mellitus on apical periodontitis healing after non-surgical endodontic treatment
- • Diabetic group-patients having type 2 diabetes mellitus, older than 18 years, non-smokers
- • Control group-healthy patients, non-smokers, older than 18 years, paired with diabetic group according to age and sex
- Exclusion Criteria:
- • 1. Influence of smoking habit on apical periodontitis healing after non-surgical endodontic treatment
- • Smoker group-systemic disease, pregnancy, taking medications that interfere with bone metabolism and immunologic response, former and occasional smokers
- • Control group-former, occasional and present smokers,systemic disease, pregnancy, taking medications that interfere with bone metabolism and immunologic response
- • 2. Influence of diabetes mellitus on apical periodontitis healing after non-surgical endodontic treatment Diabetic group-pregnancy, taking medications that interfere with bone metabolism and immunologic response, smokers Control group-patients having diabetes mellitus, pregnancy, taking medications that interfere with bone metabolism and immunologic response, smokers
About Romana Peršić Bukmir
Romana Peršić Bukmir is a dedicated clinical trial sponsor committed to advancing medical research and enhancing patient care through innovative trial designs and rigorous scientific methodologies. With a focus on ethical standards and regulatory compliance, she leads multidisciplinary teams in the development and execution of clinical studies across various therapeutic areas. Her expertise in clinical operations and commitment to patient safety ensures that trials are conducted efficiently, yielding valuable data that drives the progress of new treatments and therapies. Through collaboration with healthcare professionals and research institutions, Romana Peršić Bukmir strives to contribute meaningfully to the scientific community and improve health outcomes globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Rijeka, , Croatia
Patients applied
Trial Officials
Sonja Pezelj-Ribarić, PhD,DMD
Study Director
Faculty of Dental Medicine, University of Rijeka, Croatia
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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