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Search / Trial NCT04819269

Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome

Launched by SYLENTIS, S.A. · Mar 24, 2021

Trial Information

Current as of June 12, 2025

Completed

Keywords

Oligonucleotide Si Rna Keratoconjunctivitis Sicca Syl1001

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Subject is a male or a female aged ≥ 18 years
  • Have given their written consent to participate in the study
  • Use of artificial tears (AT), autologous serum or specific dry eye medications during the last 6 months prior to the selection
  • Willing to not use AT or autologous serum for the study duration
  • VAS scale for Dry Eye Symptom Score ≥ 40
  • Total CFS ≥ 5
  • Schirmer's test with anesthesia \< 10 mm/5min
  • Patients with Sjögren Syndrome
  • Exclusion Criteria:
  • Any concomitant treatment or prior ocular procedure or surgery, or alteration of the dose of systemic medications at the time of entry into the study
  • Use of contact lenses during the study
  • Significant Eye diseases according to investigator's opinion

About Sylentis, S.A.

Sylentis, S.A. is a biotechnology company focused on the development of innovative RNA-based therapeutics for the treatment of prevalent diseases. With a strong commitment to advancing the field of genetic medicine, Sylentis specializes in designing and delivering small interfering RNA (siRNA) treatments that target specific genes involved in various pathologies. The company’s research and clinical initiatives aim to improve patient outcomes through precision medicine, leveraging cutting-edge technologies and a robust pipeline of drug candidates. Sylentis is dedicated to collaboration with academic and industry partners to accelerate the translation of its discoveries into effective therapies.

Locations

Dothan, Alabama, United States

Scottsdale, Arizona, United States

Glendale, California, United States

Los Angeles, California, United States

Newport Beach, California, United States

Rancho Cordova, California, United States

San Diego, California, United States

Torrance, California, United States

Aurora, Colorado, United States

Colorado Springs, Colorado, United States

Littleton, Colorado, United States

Jacksonville, Florida, United States

Largo, Florida, United States

Miami, Florida, United States

Ormond Beach, Florida, United States

Tampa, Florida, United States

Atlanta, Georgia, United States

Morrow, Georgia, United States

Carmel, Indiana, United States

Waltham, Massachusetts, United States

Ypsilanti, Michigan, United States

Kansas City, Missouri, United States

Saint Louis, Missouri, United States

Washington, Missouri, United States

Asheville, North Carolina, United States

High Point, North Carolina, United States

Fargo, North Dakota, United States

Cleveland, Ohio, United States

Columbus, Ohio, United States

Cranberry Township, Pennsylvania, United States

Rapid City, South Dakota, United States

Memphis, Tennessee, United States

Nashville, Tennessee, United States

El Paso, Texas, United States

Houston, Texas, United States

Falls Church, Virginia, United States

Birmingham, Alabama, United States

Garden Grove, California, United States

Pamplona, Navarra, Spain

Barcelona, , Spain

Madrid, , Spain

Sevilla, , Spain

Valladolid, , Spain

Zaragoza, , Spain

Patients applied

TH

1 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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