HIIT and MICT on Nitric Oxide-mediated Erythrocyte Rheology
Launched by CHANG GUNG MEMORIAL HOSPITAL · Mar 26, 2021
Trial Information
Current as of April 27, 2025
Unknown status
Keywords
ClinConnect Summary
Recently, the role of erythrocyte has been more emphasized, which also related with endothelial cell. For coronary artery patients, the endothelial nitric oxide synthase activity in red blood cell (RBC-eNOS activity) is lower than age-matched health people, and it is related with dysfunction of endothelial cell. In cardiovascular diseases. the erythrocyte arginase-1 is active and seize L-arginine with eNOS. When the Arg-1 stimulated by reactive oxygen species (ROS), the nitric oxide (NO) bioactivity decrease and produce more ROS, meanwhile, ROS can go around to stimulate Arg-1. When the RBC...
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Having a sedentary lifestyle (without regular exercise, exercise frequency ≤ once weekly, duration \< 20 min).
- Exclusion Criteria:
- • Exposed to high altitudes (\> 3000 m) for at least 1 year.
- • Smoker
- • Taking medications or vitamins
- • Having any cardiopulmonary/hematological risk.
About Chang Gung Memorial Hospital
Chang Gung Memorial Hospital, one of the largest healthcare organizations in Taiwan, is renowned for its commitment to advancing medical research and improving patient care. As a clinical trial sponsor, the hospital leverages its extensive clinical expertise and state-of-the-art facilities to conduct innovative research across various medical disciplines. With a focus on collaboration and ethical practices, Chang Gung Memorial Hospital aims to contribute to the global body of medical knowledge through rigorous clinical trials that enhance treatment options and improve health outcomes for patients.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Taoyuan, , Taiwan
Patients applied
Trial Officials
Jong-Shyan Wang, PhD
Principal Investigator
Chang Gung Memorial Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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