Magnetic Resonance Imaging and Thermal Imaging of Adiposity in Neonates of Women With Metabolic Diseases

Launched by GUY'S AND ST THOMAS' NHS FOUNDATION TRUST · May 13, 2021

Keywords

ClinConnect Summary

No description provided

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Pregnant women aged between 16 and 45 years old.
• • 2. Women with GDM diagnosed at 26+0 to 30+6 weeks' gestation in accordance with the NICE guidelines Or
• • 3. Pregnant women with pre-existing type 1 or type 2 diabetes mellitus Or
• • 4. Women diagnosed with ICP at any stage of pregnancy
• • 5. Fluent in English or presence of an interpreter or translation service (i.e. telephone translation services) at all visits.
• • 6. Singleton pregnancy.
• • 7. Willing and able to give written informed consent and comply with requirements of the study protocol
• • 8. Planned antenatal, intrapartum and postpartum care at the participating centre (i.e. not planning to move before delivery)
• Exclusion Criteria:
• • 1. Known fetal congenital abnormality on ultrasound requiring fetal medicine input (excluding congenital heart disease).
• • 1. Known fetal congenital abnormality on ultrasound requiring fetal medicine input (excluding congenital heart disease).
• • 2. Significant pre-pregnancy co-morbidities that increase risk in pregnancy, for example renal failure, severe liver disease, transplantation, cardiac failure, psychiatric conditions requiring in-patient admission (within previous year) in the opinion of the responsible clinician or the CI.
• • 3. Significant co-morbidity in the current pregnancy, nephropathy (estimated GFR \<60ml/min), other physical or psychological conditions likely to interfere with the conduct of the study and/or interpretation of the study results in the opinion of the responsible clinician or the CI. (This does not include diabetes mellitus).
• • 4. History of bariatric surgery.
• • 5. Hypertension requiring treatment pre-pregnancy / in pregnancy.
• • 6. Prescribed other medications that affect insulin sensitivity prior to OGTT for women diagnosed with GDM (oral antihyperglycemic agents, antipsychotic drugs, supraphysiological doses of steroids).
• • 7. For the baby after birth: Not meeting the safety criteria to undergo MRI scan (e.g. metal implants, non MRI compatible devices, metal fragments in the body). \[ The mother will not have an MRI scan\].