The Day-time Response Variation of (Lis)Dexamphetamine

Launched by AMSTERDAM UMC, LOCATION VUMC · Jun 28, 2021

Keywords

ClinConnect Summary

Rationale: In the Netherlands, two types of amphetamines are available for the treatment of adults with ADHD: dexamphetamine sulfate (dex\[Tentin ©\]) and lisdexamphetamine dimesylate (lisdex \[Elvanse ©\]) Lisdex is promoted by the manufacturer as a long-acting preparation with a controlled release profile and thus an extended duration of action compared to dex, however, the scientific evidence about the pharmacokinetic (PK) / dynamic (PD) profile of lisdex compared to dex is sparse. Additionally, there are no head-to-head comparisons between dex and lisdex where an objective measurement f...

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Eligibility criteria

• Inclusion Criteria:
• • 1. Participant is aged between 18 - 60 years at time of diagnosis
• • 2. Participant is diagnosed with ADHD according to the DSM 5 criteria
• • 3. Participant started pharmacotherapy treatment with dex or lisdex but no real preference for the type of amphetamine exists according to practitioner
• • 4. Participant is able to provide written informed consent
• • 5. Participant is able and willing to comply with the study protocol
• Exclusion Criteria:
• • 1. No diagnosis for ADHD
• • 2. Currently other psychopharmacotherapy treatment than dex or lisdex
• • 3. Currently other psychopharmacotherapy parallel to dex or lisdex