Effect of Vitamin D in Patients With Diabetic Peripheral Neuropathy to Alleviate Pain and Improvement of Symptoms

Launched by BANGABANDHU SHEIKH MUJIB MEDICAL UNIVERSITY, DHAKA, BANGLADESH · Jul 24, 2021

Keywords

ClinConnect Summary

Diabetic peripheral neuropathy is one of the common complications of long-standing diabetes mellitus with a prevalence of 30% to 50%. It accelerates the occurrence of ulcers of diabetic foot and amputation of lower extremities as well as severely affects the quality of life. The treatment of this condition has remained unsatisfactory in spite of a good response to conventional medications. Studies showed that Vitamin D3 exerts a neuroprotective effect through the production of nerve growth factor (NGF) and neurotrophins. However, some recent trials demonstrated that vitamin D3 could be a pr...

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Eligibility criteria

• Inclusion Criteria:
• • Confirmed diagnosis of Type II Diabetes Mellitus patients who have been on anti-diabetic therapy for 1 year or more
• • Diabetic patient who meet the clinical criteria for DPN diagnosed by an endocrinologist of OPD of endocrinology
• • Age between 30 and 70 years
• • Gender: Both Male and Female
• • Patients who will give informed written consent
• Exclusion Criteria:
• • Patients suffering from other causes of peripheral neuropathy for example chemotherapy-induced neuropathy, hyperthyroidism or hypothyroidism, rheumatoid arthritis, SLE
• • Pregnant or lactating women
• • Patients with renal and liver disease, psychiatric disorder
• • Patients receiving vitamin D, vitamin B6, vitamin B12 supplementation, anticonvulsants, antidepressants, opioids, and other neuropathic pain medications within the last two months.
• • Serum calcium level: \> 10.2 mg/dl
• • HbA1c level \> 11%