Residual Paralysis and Reversal With Routine Neostigmine Versus Half-dose Sugammadex and Routine Neostigmine

Launched by KARTAL KOSUYOLU YUKSEK IHTISAS EDUCATION AND RESEARCH HOSPITAL · Sep 23, 2021

Keywords

ClinConnect Summary

Background: Postoperative residual neuromuscular block (PONB) may be observed in patients in the recovery room after surgery, and this event causes significant adverse events such as respiratory muscle weakness, decreased tidal volumes causing hypoxemia, reintubation, prolonged mechanical ventilation, and possible risk for a cardiopulmonary arrest.

Goal: The study investigators hypothesized to investigate the effects of the half-dose use of sugammadex for reversing residual blockade after administration of neostigmine and atropine and compare these results to the routine full-dose use neos...

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Eligibility criteria

• Inclusion Criteria:
• * Inclusion criteria:
• • 40 and 65 years of age,
• • American Society of Anesthesiologists Physical Status (ASA-PS) of 3 and 4,
• • Elective lower gastrointestinal tumor resection surgeries,
• • Supine positioning,
• • Surgery requiring use of general anesthesia and muscle relaxation,
• • Use of inhalational agent of sevoflurane anesthesia,
• • Surgical duration of about three to six hours.
• Exclusion Criteria:
• • History of known or suspected neuromuscular disease,
• • History of renal or hepatic dysfunction,
• • Hyperkalemia,
• • Patients receiving antibiotics, anticonvulsants, or magnesium,
• • History of stroke,
• • History of glaucoma,
• • History of pregnancy or breastfeeding,
• • Suspicion of abdominal infection or sepsis,
• • Suspected history of malignant hyperthermia,
• • An allergy to medications used during general anesthesia