Unintentional Weight Loss After Oesophagectomy

Launched by UNIVERSITY COLLEGE DUBLIN · Sep 29, 2021

Keywords

ClinConnect Summary

Oesophageal cancer accounts for 27,700 deaths per year in the European Union (1). Oesophagectomy is a key component of state of the art multi-modal (preoperative chemo\[radio\] therapy) treatment for these patients (2).

Patients may require additional chemo(radio)therapy and/ or a feeding jejunostomy for the initial period after surgery. Half of the patients remain cancer free five years after oesophagectomy (3), however many of them have unintentional weight loss as the patients involuntarily reduce food intake (4).

Prior to curative surgery, unintentional weight loss is a common present...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• A. Oesophageal adenocarcinoma group:
• • Planned for oesophagectomy with gastric conduit reconstruction
• • Recurrence-free at least 12 months post-operatively
• • Weight loss ≥10% from premorbid weight or require ongoing caloric supplementation
• B. Barrett's oesophagus group:
• • -Barrett's oesophagus group who are under surveillance from INCEUGIN
• Exclusion Criteria:
• • Pregnant or breastfeeding, or planning to become pregnant
• • Unable to swallow or need frequent dilatations ("stretches")
• • Unable to eat semisolid food
• • Allergies or dietary intolerance
• • Diabetes mellitus type 1
• • Reoccurrence of disease after surgery or are having another active form of cancer
• • Taking medication which may impact gut hormone physiology
• • Unstable cardiovascular disease
• • A significant neurological condition
• • A previous upper gastrointestinal resection
• • A medical condition that would limit the ability to take part, that might impact certain test results or might make it unsafe for the patient to take these treatments.
• • Difficulty reading, understanding or remembering the information we have given.
• • Previous abdominal surgery.
• • Treatment with GLP-1 receptor agonists or DPP-IV inhibitor or insulin