Alternate Day vs. Daily Iron Supplementation in Iron Depleted Women

Launched by SWISS FEDERAL INSTITUTE OF TECHNOLOGY · Oct 22, 2021

Keywords

ClinConnect Summary

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Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female, 18 to 45 years old,
• • SF levels \<25 μg/L,
• • Hb levels ≥ 11 g/dL
• • Normal Body Mass Index (18.5-25 kg/m2),
• • In possession of a mobile phone on which the study app can be loaded,
• • Signed informed consent,
• • Not mandatory (only for subgroup analysis): having participated in a former stable iron isotope study in our laboratory between 1-5 y ago
• Exclusion Criteria:
• • Elevated CRP \> 5 mg/L,
• • Any metabolic, gastrointestinal, kidney or chronic disease (self-reported) affecting iron metabolism,
• • Continuous/long-term use of medication, which may interfere with iron absorption, gut physiology and iron metabolism,
• • Consumption of additional iron supplements over the study period,
• • Consumption of iron supplements since screening,
• • Difficulties with blood sampling,
• • Known hypersensitivity or allergy to iron or placebo capsules in the given amount (ferrous sulfate, mannitol, silica)
• • Pregnancy, breastfeeding
• • Women who intend to become pregnant during the course of the study,
• • Known or suspected non-compliance, drug or alcohol (more than 2 drinks/day) abuse,
• • Smokers (\> 1 cigarette per week),
• • Participant is likely to be absent on one the study appointments,
• • Inability to follow the procedures of the study, e.g. due to language problems, self-reported psychological disorders, etc. of the participant.