Circadian Rhythm and Metabolic Effects of Exercise

Launched by KAROLINSKA INSTITUTET · Nov 1, 2021

Keywords

ClinConnect Summary

Exercise has well-established metabolic benefits and is a preferred intervention for Type 2 diabetes prevention and management. Metabolic determinants of exercise such as skeletal muscle and whole-body substrate oxidation capacity, glucose tolerance and insulin sensitivity and adipose tissue fatty acid release all show circadian oscillations. These rhythms may promote substantially different responses depending on the time of day when exercise is performed.

This is an exploratory study aiming to determine whether exercise at specific times of day can amplify the beneficial effects on glyce...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Body Mass Index (BMI): 23 - 33 kg/m2
• • Participants diagnosed with Type 2 Diabetes (insulin independent) or participants without Type 2 Diabetes (based on normal HbA1c and fasting glucose levels).
• • Ability to provide informed consent
• • Ability to complete the exercise regiment
• Exclusion Criteria:
• • Medications: Insulin
• • Current nicotine user (cigarettes, snus, nicotine gum) or past nicotine users less than 6 months before inclusion in the study
• • Pre-existing cardiovascular condition (Angina pectoris, Cardiac arrhythmia, Cardiac infarction, Coronary stent / angiography, Cerebrovascular insult, Hypertension \[\> 160 mmHg systolic, or \> 95 mmHg diastolic\])
• • Pre-existing blood-borne disease (HIV, Hepatitis C, MRSA)
• • Pre-existing systemic or localized rheumatic illness
• • Malignant Disease
• • Pre-existing psychiatric disorder
• • Another pre-existing systemic disease