Gut Health and Probiotics in Parkinson's (SymPD)
Launched by KING'S COLLEGE HOSPITAL NHS TRUST · Nov 23, 2021
Trial Information
Current as of April 28, 2025
Unknown status
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age of 18 and upwards
- • Diagnosis of idiopathic Parkinson's disease according to the Movement Disorder Society clinical diagnostic criteria
- • Hoehn Yarh stage II-IV
- • Diagnosis of constipation according to the ROME IV criteria and ≤ than 3 complete bowel movements per week
- Exclusion Criteria:
- • Diagnosis or suspicion of other causes for parkinsonism
- • Advanced-stage therapies (deep brain stimulation, intrajejunal levodopa infusion, and apomorphine subcutaneous infusion)
- • Any inflammatory bowel disease or diseases of the colon
- • Previous surgery on the gastrointestinal tract
- • History of laxative abuse
- • Ongoing artificial nutrition
- • Regular use of probiotics
- • Previous intolerance and/or adverse reactions to probiotics
- • Previous use of Symprove
- • Recent or current use of any antibiotics (within 4 weeks before the start of the study)
- • Swallowing issues interfering with the safety intake of the probiotic/placebo
- • Pregnancy or lactation
- • Major systemic disease
- • Any condition interfering with the ability to give the informed consent
- • Enrolment in another simultaneous investigational trial
About King's College Hospital Nhs Trust
King's College Hospital NHS Trust is a leading healthcare institution in the United Kingdom, renowned for its commitment to providing high-quality patient care and advancing medical research. With a strong emphasis on clinical excellence, the Trust supports a wide range of clinical trials across various specialties, leveraging its state-of-the-art facilities and a multidisciplinary team of healthcare professionals. By fostering innovation and collaboration, King's College Hospital NHS Trust aims to enhance treatment options and improve outcomes for patients, while contributing to the global body of medical knowledge through rigorous scientific investigation.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
London, , United Kingdom
Patients applied
Trial Officials
K Ray Chaudhuri, Professor
Principal Investigator
King's College London
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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