Prospective Database for Eosinophilic Esophagitis (EoE) of Pediatric Population

Launched by ANN & ROBERT H LURIE CHILDREN'S HOSPITAL OF CHICAGO · Dec 16, 2021

Keywords

ClinConnect Summary

This clinical trial is focused on understanding a condition called Eosinophilic Esophagitis (EoE), which is an allergic disorder affecting the esophagus, the tube that connects your mouth to your stomach. It is becoming more commonly diagnosed in children, and researchers want to learn more about what causes it and how it relates to other allergic conditions, like asthma and skin allergies. The study will involve collecting and analyzing information from patients with EoE at Ann & Robert H. Lurie Children's Hospital, as well as looking at patients who may have EoE but haven't been officially diagnosed yet.

To participate in this trial, patients need to have a confirmed diagnosis of EoE, which is usually identified through a procedure called endoscopy, where doctors look inside the esophagus and take small tissue samples. Alternatively, children who show symptoms of EoE but have not yet been diagnosed can also be included as control patients. Participants will help researchers understand the condition better, which may lead to improved treatment options in the future. It’s important to note that anyone who does not agree to participate cannot be included in the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -Patients with an established diagnosis of EoE, based on endoscopy with biopsies with ≥15 eosinophils per hpf in esophageal biopsies after symptoms of esophageal dysfunction persist despite at least 6-8 weeks of appropriate acid suppression therapy.
• • OR
• • -Patients who are suspected of having EoE (presenting with symptoms of esophageal dysfunction non-responsive to appropriate proton pump inhibitor therapy for 6-8 weeks).
• • • Note: Patients suspected of having EoE but not diagnosed with EoE by endoscopy with biopsies will serve as control patients
• Exclusion Criteria:
• • Patients who do not consent to participate