VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs

Launched by VIVEX BIOLOGICS, INC. · Jan 14, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called VIA Disc NP, which is designed to help people suffering from back pain caused by degenerated discs in the spine. The goal of the trial is to see if this treatment can effectively supplement the damaged tissue in the discs and relieve symptoms of chronic low back pain. To be eligible for the trial, participants need to be at least 18 years old, have a specific type of disc degeneration verified by MRI, and have experienced chronic back pain for six months or longer. They must also have tried at least two conservative treatments, like physical therapy or pain medications, without success.

Participants in the trial can expect to undergo a thorough evaluation to determine their eligibility, which includes a review of their medical history and imaging results. If accepted into the trial, they will receive the VIA Disc NP treatment and will be monitored throughout the study. It’s important to note that there are several conditions that may disqualify someone from participating, such as having a history of certain spinal conditions or other major health issues. Overall, this trial aims to explore a potential new option for those who have not found relief from traditional treatments for their back pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Eligibility for inclusion is evaluated on a site-specific basis based on each subject's medical, clinical, and radiographic presentation. In addition, for study consistency purposes, the MRI imaging will be submitted to Medical Metrics Imaging (MMI), a core lab, for independent review. MMI will review imaging of every subject to confirm radiographic inclusion criteria. The Medical Monitor will make the final determination for inclusion on all subjects based on review of the MRI relevant medical history and source documents.
• • 1. Age 18 years or older;
• • 2. Body mass index (BMI) \< 35;
• • 3. Documented diagnosis of moderate radiographic degeneration of up to 2 intervertebral discs from L1 to S1, with a suspected associated discogenic chronic low back pain;
• • 4. Chronic LBP for ≥ 6 months;
• 5. Failed conservative care over the past 3 months of at least 2 conservative treatments including:
• • 1. oral pain medication \[analgesics, steroids and/or non-steroidal anti-inflammatory drugs (NSAIDs)\],
• • 2. structured physical therapy or exercise program prescribed by physical therapist, chiropractor, provider or physician specifically for the treatment of low back pain, and
• • 3. epidural steroid injections and/or facet injections/selective nerve blocks;
• 6. An MRI demonstrating:
• • 1. 1 to 2 vertebral level involvement L1-S1;
• • 2. Modified Pfirrmann Grade 3-7;
• • 3. No modic changes or if changes ≤ 2;
• • 7. Oswestry Disability Index (ODI) score at time of evaluation of ≥ 40 and ≤ 80 points;
• • 8. Low back pain of Baseline Numeric Rating Scale (NRS) score of ≥ 6 on the 11-point scale;
• • 9. No signs or symptoms of current infection;
• • 10. Be able to give voluntary, written informed consent to participate and have signed an Informed Consent Form specific to this study;
• • 11. Be willing and able to comply with all study procedures and availability for the duration of the study with a life expectancy of \> 2 years.
• Exclusion Criteria:
• • 1. Known allergies to Gentamicin, Vancomycin;
• • 2. Contraindications to the proposed sedation/anesthetic protocol;
• • 3. Radicular pain greater than back pain by history or evidence of radicular pain or neurological deficit within the past 6 months. Radicular pain is defined as nerve pain following a dermatomal distribution and that correlates with nerve compression on imaging. Somatic referred pain is allowed;
• 4. Any of the following conditions at the index level:
• • 1. Contained disc protrusion \>5 mm or disc extrusion, or spondylolisthesis \>5 mm (lysis and degenerative);
• • 2. Seronegative spondyloarthropathy;
• • 3. Symptomatic spinal stenosis (moderate to severe in degree);
• • 4. Chronic facet syndrome;
• • 5. Spondylodiscitis;
• • 6. Bilateral spondylolysis;
• • 7. Current or history of osteoporotic or tumor-related vertebral body compression fracture;
• • 8. Previous lumbar spine fusion surgery or disc arthroplasty;
• • 5. History of sacroiliac (SI) joint pain/injections during the past 3 months or SI joint fusion within the past two years;
• • 6. Received chemonucleolysis or percutaneous treatment of the affected disc prior to the study;
• • 7. History of epidural steroid injections within 1 week prior to study treatment;
• • 8. Received any lumbar intradiscal treatment injection or procedure (e.g., injection of methylene blue, dextrose, glucosamine, and chondroitin sulfate, or biacuplasty) and any nerve ablation procedures at the same or adjacent level (e.g., Basivertebral nerve ablation, dorsal ramus or sinovertebral nerve ablations). Discography and anaesthetic discography may be performed but must be done at least 2 weeks or more prior to the injection procedure;
• • 9. Been a recipient of prior stem cell/progenitor cell therapy or other biological intervention (e.g., PRP) to repair the target intervertebral disc;
• • 10. Severe motor deficit or cauda equina disorder based on investigator determination;
• • 11. Diagnosis of any traumatic neurological disorders;
• • 12. Severe diseases of any other major body system as judged by the investigator, including malignant diseases of any solid organ or any hematologic malignancy during the previous 5 years;
• • 13. Demonstrate 3 or more Waddell's signs of Inorganic Behavior;
• • 14. Any mental instability, bipolar disorders, post-traumatic stress disorder (PTSD) or uncontrolled anxiety/depression and/or require new or changed anti-depressants or anti-psychotic medications within 3 months of enrollment;
• • 15. Compensated injuries or ongoing litigation regarding back pain/injury, or financial or other incentives to remain impaired;
• • 16. If female and of child-bearing potential, are pregnant or breastfeeding or a plan to become pregnant or breastfeed in the first 12 months post-treatment;
• • 17. Any medical condition that impairs follow-up (i.e., fibromyalgia, rheumatoid arthritis, chronic regional pain syndrome, reflex sympathetic dystrophy);
• • 18. Evidence of substance abuse (including marijuana); Note: subjects using prescribed extended-release narcotics (e.g., fentanyl patch, MS Contin, oxycontin) within the 3 months prior to screening; subjects on long-acting opioids may be given option to wean off opiates before enrollment. Subjects on short-acting opiates (e.g., hydrocodone, oxycodone, tramadol, etc.) may be included and utilization monitored after the treatment;
• • 19. Are currently receiving treatment with radiation, chemotherapy, immunosuppression, or chronic steroid therapy (prednisone, or its equivalent, use of up to 5 mg/qd is allowed, as well as inhalation steroids for asthma);
• • 20. Active implantable devices, such as cardiac pacemakers, spinal cord stimulators, intrathecal pumps, etc.
• • 21. Bilateral spondylolysis at any level;
• • 22. Fracture of the spine, previous lumbar spine surgery or previous treatment of the target disc.