Outcome of Glargine Insulin in Renal Impairment Patients With Diabetic Ketoacidosis

Launched by AIN SHAMS UNIVERSITY · Jan 21, 2022

Keywords

ClinConnect Summary

Diabetic ketoacidosis (DKA) is one of the most common and grave acute complications of diabetes and is a significant cause of morbidity and mortality.

The current available guidelines state that the most effective means of insulin delivery during DKA is a continuous low dose infusion of regular insulin. The patients must be admitted to the ICU for frequent and close monitoring .In addition to insulin infusion, correction of dehydration, and electrolyte and acid base disorders is achieved together with identification and treatment of co-morbid precipitating factors .

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Eligibility criteria

• Inclusion Criteria:
• • Male and female patients.
• • Type I and type II diabetes mellitus.
• • Patients on insulin and/or oral hypoglycemic therapy.
• • Duration of diabetes more than 5 years.
• • Medical and surgical patients.
• Exclusion Criteria:
• • Severe persistent hypotension (SBP \<80 inspite of receiving 1000ml of normal saline).
• • Acute myocardial infarction.
• • Progressive renal failure or end stage renal disease defined as eGFR \< 15ml/min.
• • Liver cell failure.
• • Pregnancy.
• • Need for emergency surgery