Gastro-intestinal Physiology After Anti-Reflux Procedures

Launched by ST GEORGE'S, UNIVERSITY OF LONDON · Feb 11, 2022

Keywords

ClinConnect Summary

GORD is caused by backflow of stomach contents, including acid and bile into the oesophagus. It can lead to distressing symptoms such as heartburn, regurgitation, and chest pain. It is more common in men, smokers, advanced age, obesity and consumption of fatty foods and alcohol. The mechanism of GORD can be complex and multifactorial. The best appreciated mechanism is reduced pressure of the lower oesophageal sphincter (LOS) or excessive transeient relaxations of the LOS (TLOSR), which allows stomach contents to reflux into the oesophagus. Hiatus hernia can cause GORD by a similar mechanism...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient under the care of St George's University Hospital NHS Foundation Trust, London
• • Decision to specifically undergo Stretta procedure, laparoscopic fundoplication or LINX device (N.B. this study will have no involvement in that decision or choice of procedure)
• • Symptoms compatible with GORD, e.g. heartburn, regurgitation, chest pain
• • Physiological evidence of GORD, e.g. endoscopy, HRM, pH studies
• • Male or Female
• • Age 18 to 90
• Exclusion Criteria:
• • Patients \< 18 years old or \>90 years old
• • Patients with significant medical co-morbidities
• • Patients unable to provide consent for study participation
• • Patients unable to easily attend hospital for the physiological tests
• • Patients who have had complications from their anti-reflux procedure
• • Patients who have previously undergone oesophageal surgery