Effect of Degree of Polymerization and Linkage of α-glucans on Post-prandial Glucose Response

Launched by SOCIÉTÉ DES PRODUITS NESTLÉ (SPN) · Mar 3, 2022

Keywords

ClinConnect Summary

The aim of the present research project is to generate comparative data on post-prandial glucose response (PPGR) of α-glucans varying systematically degree of polymerization and linkage type. These data are expected to contribute to the sugar replacement strategy in food industry.

An additional goal of the study is to demonstrate the feasibility of running a PPGR study remotely, i.e. with the participants carrying out most of the procedures at home.

Remote clinical trials (so called "virtual") have recently started to be implemented in pharmaceutical clinical research with the intent to r...

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Eligibility criteria

• Inclusion Criteria:
• • Male and female participant
• • Healthy status (based on anamnesis)
• • Age between 18 and 45 years
• • BMI between 18.5 and 29.9 kg/m2
• • Able to understand and sign an informed consent form
• • Able to respect the study procedures and timelines
• • Swiss resident living in canton Fribourg (French part), Neuchâtel, Vaud and Valais which is in the competence of Ethical Committee of Vaud
• • Having wireless internet access at home
• Exclusion Criteria:
• • Any known metabolic disease including diabetes or drug chronic intake (aspirin, vitamin C and mineral supplements, steroids, protease inhibitors, antidepressants, anxiolytic, or antipsychotics...) possibly impacting (to the opinion of the medical responsible): The digestion or absorption of nutrients, the postprandial glucose response
• • Major medical/surgical event requiring hospitalization in the last 3 months
• • Pregnancy or lactation
• • Known food allergy and intolerance
• • Medically known cutaneous hypersensitivity to adhesives, silicon watch-strap and plasters
• • Alcohol intake higher than 2 servings per day. A serving is 0.4 dl of strong alcohols, 1 dl of red or white wine, or 3 dl of beer.
• • Smokers
• • Participant having a hierarchical link with the research team members