Psychological Interventions for Complex PTSD And Schizophrenia-Spectrum Disorder: PICASSO Trial

Launched by EDINBURGH NAPIER UNIVERSITY · Mar 11, 2022

Keywords

ClinConnect Summary

BACKGROUND \& RATIONALE FOR STUDY

Psychosis, characterised by unusual experiences such as delusions and hallucinations, is commonly associated with a diagnosis of schizophrenia. It affects up to 3% of the population, and individuals with this condition often experience high levels of distress, a loss of ability to plan and work, and a loss of interpersonal relationships. People with psychosis die 15-20 years earlier than the general population, however existing treatments for psychosis have at best modest effects on symptoms and related distress. Consequently, many thousands of people are ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of schizophrenia-spectrum disorder (confirmed using Clinical Interview for Psychotic Disorder, CIPD)
• • Presence of symptoms of Affect Dysregulation, Negative Self Concept or Disturbed Relationships as a result of exposure to traumatic life events (confirmed using the Trauma and Life Events Checklist, TALE and the International Trauma Questionnaire, ITQ - at least one of the two symptoms ≥2)
• • Aged 18-65
• • Have a mental health keyworker.
• Exclusion Criteria:
• • Primary diagnosis of alcohol, substance-use disorder or bipolar affective disorder
• • Developmental disability
• • Non-English speaking
• • Lacking capacity to consent to participate
• • Unmanageable risk of violence to research or clinical staff (as judged by research team)
• • Significant risk of harm to self that is not being adequately managed by existing mental health services (as judged by research team).