The Effect of Pretreatment With Dydrogesterone Vs Combined Estradiol Valerate and Dydrogestrone on Clinical Pregnancy Outcome of ICSI in PCOS Patients"

Launched by SOHAG UNIVERSITY · Mar 19, 2022

Keywords

ClinConnect Summary

Polycystic ovary syndrome (PCOS) is a very common endocrine disorder affecting 5-7% of women in reproductive age. It is the leading cause of anovulatory infertility in this age group. It is characterized by ovulatory dysfunction, hyperandrogenism and polycystic ovary morphology on ultrasonography.

Assisted reproductive techniques (ART) are indicated when infertile women with PCOS are unable to become pregnant through standard ovulation induction methods. Many protocols have been used for ovulation induction in ICSI , GNRH agonist and GNRH antagonist protocols are the most commonly used now...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • -Women with PCOS undergoing their first cycle of ICSI. PCOS diagnosis will be performed based on Rotterdam criteria (2003) based the presence of oligomenorrhea, polycystic ovaries on ultrasonography (defined as either an ovary that contains ≥ 12 antral follicles or ovarian volume\>10cm3) as well as biochemical or clinical signs of hyperandrogenism, and after exclusion of other causes of hyperandrogenism as Cushing syndrome and CAH and hypothyroidism.
• • age 18 to 35 years.
• • BMI between 19 and 25 kg/square meter.
• • AMH 3.5-6 ng/ml
• • fresh or frozen embryo transfer
• Exclusion Criteria:
• • -FSH more than 12 IU /L
• • AFC- performed on day 3 of the cycle- less than 4
• • Existence of hydrosalpinx on ultrasonography
• • uterine disorders as that caused by uterine fibroids.
• • -. All male partners should have normal semen parameters .
• • Women with more than 20 oocytes
• • Any sign of early onset OHSS