Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer

Launched by LONDON HEALTH SCIENCES CENTRE RESEARCH INSTITUTE OR LAWSON RESEARCH INSTITUTE OF ST. JOSEPH'S · Mar 29, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how well two different types of MRI scans work in finding liver cancer that has spread from colon cancer. After a patient is diagnosed with colon cancer, doctors often use a CT scan to check if the cancer has spread to the liver. If they see something unusual, an MRI is usually done to get more information. This study is comparing a regular MRI, which takes about an hour, with a shorter version that could take just 15 minutes. Researchers want to see if the shorter MRI is just as effective in detecting liver tumors, which is important for planning treatment.

To participate in this trial, you need to be at least 18 years old and have been diagnosed with colon cancer that has spread to the liver, confirmed by a biopsy. You should also have already had imaging showing liver lesions. Participants will undergo an MRI scan using a special contrast agent that helps highlight any cancerous areas in the liver. It's important to note that people with certain medical conditions, like severe claustrophobia or specific implanted devices, may not be eligible to join the study. Overall, this trial aims to improve how we detect liver metastases in colon cancer, which can help doctors provide better care for their patients.

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Eligibility criteria

• Inclusion Criteria:
• • Male or female, 18 years of age or older
• • Diagnosis of colorectal cancer, biopsy proven
• • Prior imaging showing liver lesions that may be metastases
• • Provision of signed and dated informed consent form
• • Willingness to comply with study procedures and availability for the duration of the study
• • Able to tolerate MRI required by protocol
• Exclusion Criteria:
• • Presence of implanted medical device or metallic object that is MR incompatible
• • Baseline eGFR of \< 30 mL/min/1.73 m2
• • Severe claustrophobia not relieved by oral anxiolytics
• • Documented severe allergic-like reaction gadolinium-based contrast agent
• • Weight greater than allowable on MRI table
• • Pregnancy
• • Diffuse liver metastases, i.e. definitively unresectable
• • Severe liver dysfunction, ALBI grade 3