Cumulus Cell Mitochondrial Activity as a Non-invasive Marker of Embryo Quality (FLIM)

Launched by MỸ ĐỨC HOSPITAL · Apr 10, 2022

Keywords

ClinConnect Summary

This clinical trial, called the FLIM study, is looking at a new way to assess the quality of embryos during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Researchers want to see if they can use a special imaging technique called Fluorescence Lifetime Imaging Microscopy (FLIM) to measure the activity of cumulus cells—cells that surround and support the egg. By understanding how these cells behave, the study hopes to find a link between their activity and successful outcomes like clinical pregnancies, ongoing pregnancies at 12 weeks, and live births.

To participate in this study, women aged 18 and older who are undergoing IVF or ICSI must meet certain criteria. They need to have had at least 8 follicles (small fluid-filled sacs containing eggs) visible during an ultrasound before ovulation. Participants will agree to freeze all their embryos and have a single embryo transferred on day 5 or 6 after fertilization. If you choose to join, you will help researchers gather important information that could improve future IVF treatments.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Having any number of IVF/ICSI attempts
• • Ovarian stimulation with any stimulation protocol
• • Patients with at least 8 follicles ≥ 10 mm on ultrasonography at induced ovulation date
• • Agreed to freeze-all day 5-6 embryos
• • Agreed to have a single day 5-6 embryo transfer.
• • Agreed to participate in the research (signed the consent form)
• Exclusion Criteria:
• • In vitro maturation (IVM) cycles
• • Cycles using testicular biopsy or epididymal sperm
• • Cycles not having an oocyte freeze-all cycle
• • Cycles using standard insemination
• • Participating in another research