REward SYSTem in Autism Spectrum Disorder and Addictive Disorder

Launched by UNIVERSITY HOSPITAL, TOURS · May 20, 2022

Keywords

ClinConnect Summary

The REward SYSTem clinical trial is studying how the brains of adults with Autism Spectrum Disorder (ASD) and those with Food Addiction Disorder (FAD) work compared to healthy individuals. This research aims to better understand the differences in brain function and structure among these groups. The trial is currently looking for adult participants aged 18 and older who fall into one of three categories: adults diagnosed with ASD, adults diagnosed with food addiction, or healthy volunteers with no history of neurological or psychiatric issues.

To participate, individuals must have an IQ above 70 and be able to follow instructions during activities. Participants will undergo MRI scans, which are safe imaging tests that allow researchers to see inside the brain. It's important to note that certain health conditions, like serious visual problems or epilepsy, may prevent someone from joining the trial. If you or a loved one meets the criteria and is interested, this study could provide valuable insights into how these disorders affect brain function.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Arm A ˗ Concerning ASD patients: Adult carrying the diagnosis of ASD (DSM-5, ADOS, ADI-R criteria)
• • Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES \>= 18 criteria).
• • Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk.
• For all participants:
• • Age greater than or equal to 18 years old
• • Without intellectual delay (IQ \> 70).
• • Able to understand and apply the instruction when an active task is proposed, according to the estimate of the investigator.
• • Free, express, informed and written consent of the participant.
• • Participant affiliated to a social security scheme
• Exclusion Criteria:
• • Neuromotor disorders.
• • Visual disturbances not corrected or incompatible with MRI.
• • Known epilepsy.
• • Current substance use disorder with emotional distress/significant impact on functional outcome
• • Rare genetic syndrome.
• • Contraindications to MRI (other than body circumference)
• • For women of childbearing age: negative urine or blood pregnancy test
• • Person subject to a measure of judicial protection (safeguard of justice, curatorship, guardianship or family authorization)