The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) Study

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Jul 15, 2022

Keywords

ClinConnect Summary

The MOVE PAH Study is a clinical trial designed to help patients with pulmonary arterial hypertension (PAH), a condition that affects blood flow in the lungs and can make breathing difficult. This study is looking at whether sending smart text messages can improve patients' quality of life and ability to exercise compared to usual care over six months. Researchers will enroll 100 adults aged 18 and older who have been diagnosed with different forms of PAH, as long as they are stable on their medications and can participate in some level of physical activity.

Participants in this trial will receive either the smart text messages or standard care and will be asked to complete a special questionnaire to assess their quality of life. They will also do a walking test at home to measure their exercise capacity. The study will track how well participants do over the next year, including any changes in their health or the need for more intense treatment. This trial is important because it aims to find a more practical way for PAH patients to increase their physical activity, which could significantly improve their health and life quality.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged 18 or older.
• • Diagnosed with idiopathic, heritable, or associated (connective tissue disease, drugs, or toxins) pulmonary arterial hypertension (PAH), or PAH due to simple congenital heart disease (i.e. atrial septal defect).
• • WHO functional class I-III
• • Stable PAH-specific medication regimen for three months prior to enrollment. Subjects with only a single diuretic adjustment in the prior three months will be included. Adjustments in IV prostacyclin for side effect management are allowed.
• • Forced vital capacity \>65% predicted with no or minimal interstitial lung disease based on reviews of imaging studies by PI and medical monitor.
• Exclusion Criteria:
• • Prohibited from normal activity due to wheelchair bound status, bed bound status, reliance on a cane/walker, activity-limiting angina, activity-limiting osteoarthritis, or other condition that limits activity.
• • Pregnancy
• • Diagnosis of PAH etiology other than idiopathic, heritable, or associated.
• • Functional class IV heart failure
• • Requirement of \> 2 diuretic adjustment in the prior three months.
• • Preferred form of activity is not measured by an activity tracker (swimming, yoga, ice skating, stair master, or activities on wheels such as bicycling or rollerblading).

Trial Officials