Cold or Hot Snare Endoscopic Mucosal Resection for 10-19mm Non-pedunculated Colorectal Polyps

Launched by QINGWEI JIANG · Sep 15, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating two different methods for removing non-pedunculated colorectal polyps, which are small growths in the colon, sized between 10-19 mm. The study is comparing cold snare endoscopic mucosal resection (CS-EMR) and hot snare endoscopic mucosal resection (HS-EMR) to see which method is more effective and safer for patients. If you are between 18 and 80 years old and are scheduled for a colonoscopy at specific hospitals in China, you might be eligible to participate, especially if doctors have found at least one suitable polyp during your colonoscopy.

Participants in the study will be randomly assigned to receive either CS-EMR or HS-EMR during their procedure. The aim is to gather more information about how well each technique works and to ensure that patients have a safe experience. It's important to note that certain health conditions, such as severe heart or lung issues, recent surgeries, or pregnancy, may prevent individuals from taking part in the study. If you choose to participate, you will be asked to sign a consent form, and your doctors will explain everything you need to know about the procedure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-80 years of age;
• • undergo colonoscopy in the Digestive Endoscopy Center of Peking Union Medical College Hospital, Beijing Tsinghua Changgung Hospital or Seventh Medical Center, General Hospital of the Chinese People's Liberation Army;
• • volunteer to participate in this study and sign informed consent;
• • at least one polyp sized 10-19 mm (Paris classification Is or IIa) by colonoscopy.
• Exclusion Criteria:
• • American Society of Anesthesiologists (ASA) status class 3 or above;
• • poor bowel preparation (Boston bowel preparation scale \< 6 points);
• • known or endoscopic features indicating the submucous infiltration or malignancy;
• • oral anti-coagulants, or antiplatelet agents, or known blood coagulation disorders, or bleeding tendency (platelets\<50000 cells/mm3 or INR\>1.5);
• • a history of colorectal resection;
• • emergency colonoscopy (hemodynamic instability and/or continued active gastrointestinal bleeding and/or requiring intensive care patients);
• • inflammatory bowel disease, familial polyposis, and colorectal cancer;
• • pregnancy or lactation;
• • severe cardiopulmonary dysfunction, liver cirrhosis, chronic kidney disease, other malignant tumors, or severe infectious diseases.