Short-term Outcomes of Full Bowel Preparation (MBP+OA) for Colon Cancer Resections Versus no Bowel Preparation

Launched by N.N. PETROV NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY · Sep 15, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating whether a specific way of preparing the bowel before colon cancer surgery leads to better short-term outcomes than having no preparation at all. The preparation being studied involves a combination of mechanical bowel preparation (which involves clearing out the intestines) and taking oral antibiotics. Researchers want to find out if this approach helps patients recover more effectively after their surgery.

To join the study, participants must be at least 18 years old and have a confirmed diagnosis of colon cancer that is operable. They should be in reasonably good health, meaning they can perform daily activities with little assistance. However, certain conditions may prevent someone from participating, like being pregnant, having other serious medical issues, or having had antibiotics recently. If you choose to take part, you will receive care and support throughout the trial, and the results may help improve future treatment for colon cancer patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • histologically confirmed adenocarcinoma of the colon (caecum, ascending, transverse, descending, sigmoid)
• • clinical stage T1-4aN0-2M0-1 (distant metastases must be resectable)
• • indications for surgical colonic resection
• • ECOG status 0-2
• • At least 18 years of age
• • Written informed consent
• Exclusion Criteria:
• • Medical or psychiatric conditions that compromise the patient's ability to give informed consent or comply with the study protocol
• • Pregnancy or breast feeding
• • Medical contraindications for surgical treatment
• • Any use of antibiotics 30 days prior to inclusion
• • Functioning stoma
• • Contraindications for use of MBP or OA drugs or their components
• • Indications for mandatory MBP (planned intraoperative colonoscopy etc)
• • Indications for obstructive resection
• • Acute bowel obstruction, bleeding or perforation
• • Other malignancies not in remission