Effect of Acute Bout of Exercise on Levels of PAHSA

Launched by LENKA ROSSMEISLOVA · Oct 5, 2022

Keywords

ClinConnect Summary

This clinical trial, called the Effect of Acute Bout of Exercise on Levels of PAHSA (ETAPA), is studying how exercise affects certain substances in the body that may help improve insulin sensitivity. Insulin sensitivity is important for preventing conditions like type 2 diabetes and heart disease, especially in people who are overweight or aging. Researchers want to understand how both short-term and long-term exercise can increase levels of a substance called PAHSA, which has been shown to help reduce inflammation and improve insulin function.

To participate, you need to be a healthy young adult or elderly person, and you should not have certain medical conditions or be taking specific medications that could interfere with the study. Participants will undergo some assessments, which may include blood draws and a small procedure to take a sample of fat from the abdomen. This study is currently looking for volunteers, and it aims to provide important insights that could lead to better treatments for metabolic disorders linked to obesity and aging.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • healthy young lean, young obese and elderly omnivorous men and women as defined by BMI, self-reported activity, self-reported medical history and self-reported diet assessment
• • must be able to withstand repeated blood draws
• • must be able to undergo abdominal fat biopsy
• Exclusion Criteria:
• • use of betablockers
• • use of glucocorticoids
• • use of non-steroidal anti-inflammatory drugs
• • use of metformin in prediabetes
• • use of psychiatric drugs such as selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, anticonvulsants and others
• • oncologic malignancy
• • chronic inflammatory or autoimmune diseases
• • diabetes mellitus
• • chronic ischemic heart disease
• • cardiovascular and pulmonary disease
• • renal and hepatological disease as assessed per biochemistry
• • musculo-skeletal deviations limiting physical performance
• • substance abuse
• • other than omnivorous diet