A Probiotic Blend Reduces Gastrointestinal Symptoms and Positively Impacts Microbiota Modulation in a Randomized Study

Launched by THE CENTER FOR APPLIED HEALTH SCIENCES, LLC · Nov 11, 2022

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Eligibility criteria

• Inclusion Criteria:
• • all participants were required to be between 30-60yr
• • score ≥12 on the GSRS
• • have a body mass ≥120 pounds (54.5kg)
• • body mass index (BMI) between 20.0-34.99kg/m2
• • normotensive (\<140/\<90mmHg)
• • normal resting heart rate (\<90bpm)
• Exclusion Criteria:
• • Female participants who were pregnant or nursing
• • history of unstable or new-onset cardiovascular or cardiorespiratory disease;
• • stroke, diabetes, or other endocrine disorder;
• • use of any nutritional supplement known to alter the gut microbiota/microflora;
• • use of probiotic supplements or prebiotic supplements in the previous 4 weeks and for the duration of the study;
• • use of any antibiotics, antifungals, antivirals, or antiparasitic within 8 weeks of the start of the study or throughout the study;
• • any changes in diet within 4 weeks of study start date or throughout study duration;
• • if the participant was unwilling to abstain from gut altering supplements for the study;
• • malignancy in the previous 5yr except for non-melanoma skin cancer (basal cell cancer or squamous cell cancer of the skin);
• • prior gastrointestinal bypass surgery (i.e., Lapband);
• • any known gastrointestinal or metabolic diseases that might impact nutrient absorption or metabolism \[e.g. short bowel syndrome, diarrheal illnesses, history of colon resection, gastroparesis, Inborn-Errors-of-Metabolism (such as PKU)\];
• • any chronic inflammatory condition/disease (e.g. rheumatoid arthritis, Crohn's disease, ulcerative colitis, Lupus, HIV/AIDS, etc.);
• • known sensitivity to any ingredient in the test formulations as listed in the certificates of analysis.
• • currently participating in another research study with an investigational product or had participated in another research study in the past 30 days
• • any other diseases/conditions that, in the opinion of the medical staff, could confound the primary endpoints or place the subject at increased risk of harm if they were to participate.