Jet or Vibrating Mesh Nebulisation for Secretion Management in ICU

Launched by NHS GREATER GLASGOW AND CLYDE · Nov 22, 2022

Keywords

ClinConnect Summary

This clinical trial is studying two different types of nebulisers—jet nebulisers and vibrating mesh nebulisers—to see which one works better for helping critically ill patients manage their respiratory secretions in the Intensive Care Unit (ICU). When patients are very unwell, their ability to clear mucus can be reduced, which can lead to complications, including the need for reintubation (putting a breathing tube back in). The trial aims to find out if one type of nebuliser can help clear these secretions more effectively, making it easier for patients to breathe.

To be eligible for the trial, participants need to be between 18 and 80 years old, currently on a ventilator with a breathing tube, and have a significant amount of mucus that requires suctioning at least twice in the six hours before joining the study. It's important that they haven't received saline nebulisation in the six hours prior to recruitment and are expected to be on the ventilator for at least three more days. If someone is pregnant or has certain heart or lung conditions, they won't be able to participate. Participants in the trial will receive either type of nebulisation to help manage their secretions, and the study will closely monitor their progress. This research could lead to better care for patients in critical situations.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient aged 18-80 years at time of recruitment to study
• • Ventilated via an endotracheal tube or tracheostomy with an HME filter in the circuit
• • Secretion load defined as patient requiring suctioning at least 2 times in the 6 hours prior to recruitment
• • Sputum viscosity with grades 1 to 3 pourability in the Qualitative Sputum Assessment tool
• • Not yet received saline nebulisation in the 6 hours prior to recruitment
• • Likely to be ventilated via an endotracheal tube or tracheostomy for at least 3 days in the opinion of the treating clinician
• Exclusion Criteria:
• • Pregnancy
• • Pulmonary embolus
• • Heart Failure (NYHA Grade III/IV)
• • Clinical evidence of frank pulmonary oedema
• • Cardiovascular instability (systolic BP ≤75 or heart rate ≥140)