Advanced Invasive Diagnosis for Patients With Chronic Coronary Syndromes Undergoing Coronary ANGIOgraphy (AID-ANGIO)

Launched by HOSPITAL SAN CARLOS, MADRID · Nov 22, 2022

Keywords

ClinConnect Summary

AID-ANGIO is designed as an observational, prospective, single arm, longitudinal study, intended to assess the diagnostic yield of a hierarchical strategy which investigates both obstructive and non-obstructive causes of myocardial ischaemia in patients with CCS at the time of ICA. The diagnostic algorithm starts with an ICA. Angiographically severe-grade stenosis (≥70%) can be safely considered flow-limiting without further physiological assessment. Conversely, by means of a pressure guidewire, intermediate-grade stenosis should be evaluated with FFR and/or NHPR in order to determine if th...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with CCS, referred to ICA by their clinicians, suffering from angina and/or positive evidence of ischaemia in non-invasive tests and/or presence of CAD in computed tomography angiography.
• Exclusion Criteria:
• • Age \<18 or \>90 years old.
• • Pregnancy.
• • Severe left ventricle systolic dysfunction (LVEF ≤30%) or congestive heart failure.
• • Any concomitant severe valve disease. Severely decreased renal function (glomerular filtration rate \<30 mL/min/1.73 m2).
• • Previous CABG.
• • Presence of any anatomic features hampering intracoronary instrumentation with pressure guidewires.
• • Contraindications to the administration of adenosine (asthma, 2nd or 3rd grade atrioventricular block without pacemaker, history of a non-ablationed accessory pathway-mediated tachycardia) or acetylcholine (asthma, 2nd or 3rd grade atrioventricular block without pacemaker, paroxysmal atrial fibrillation).