A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors

Launched by DEBIOPHARM INTERNATIONAL SA · Jan 20, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring the safety and effectiveness of a new treatment called [177Lu]Lu-DPI-4452 for patients with certain types of advanced cancers, specifically clear cell renal cell cancer, pancreatic ductal adenocarcinoma, and colorectal cancer. The study has three parts: the first part checks how safe and tolerable an initial dose of a related substance, [68Ga]Ga-DPI-4452, is when given through an IV; the second part aims to find the best dose of [177Lu]Lu-DPI-4452; and the third part looks at how well this treatment can shrink tumors. The trial is currently recruiting participants aged 65 and older who have already undergone specific prior treatments for their cancer.

To be eligible for the trial, participants must have advanced cancer that cannot be surgically removed and have already received certain previous treatments. They also need to have a tumor that can be measured through imaging tests. Participants can expect to receive close monitoring during the trial to ensure their safety, and they’ll be helping to advance our understanding of new cancer treatments. It's important to note that there are specific health criteria and prior treatment requirements for joining, so potential participants should discuss their situation with a healthcare provider.

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Eligibility criteria

• Inclusion Criteria:
• Part A, B, and C:
• • Written informed consent, dated and signed by the patient prior to any study-specific procedure.
• • Part B and C are not conducted in the United States of America.
• * Has histologically or cytologically confirmed, unresectable locally advanced or metastatic solid tumors of:
• • Clear cell renal cell cancer (ccRCC) - participants must have received at least one line containing Tyrosine kinase inhibitor (TKI) treatment and at least one line containing immune checkpoint inhibitor treatment in metastatic setting, meaning at least two lines of treatment in metastatic setting.
• • Pancreatic ductal adenocarcinoma (PDAC) - participants must have received at least one line of platinum- and/or gemcitabine-based regimen.
• • Colorectal cancer (CRC) - participants must have received at least one line of FOLFIRINOX or FOLFOX/FOLFIRI in two lines in combination with anti-Vascular Endothelial Growth Factor (VEGF) or anti-Epidermal Growth Factor Receptor (EGFR).
• • Participants with CRC or PDAC: availability of fresh biopsy, OR an archival biopsy/surgical specimen of the tumor (preferably, taken after last prior line of therapy).
• • Presence of at least 1 non-irradiated tumor lesion detected at conventional imaging (computed tomography / magnetic resonance imaging (CT/MRI)) documented within 4 weeks prior to the \[68Ga\]Ga-DPI-4452 administration.
• • Measurable disease per response evaluation criteria in solid tumors (RECIST) v1.1.
• Part D:
• • Participants with imaging evidence of a single indeterminate renal mass (IDRM) of ≤ 7 cm in largest diameter (tumor stage cT1) on any conventional diagnostic imaging technique, suspicious for ccRCC and planned for total or partial nephrectomy, or interventional diagnostic (cystoscopy and retrograde pyelography or biopsy) within 90 days from planned \[68Ga\]Ga-DPI-4452 administration.
• Part E:
• • Regardless of lines of treatment, participants with histologically or cytologically confirmed progressive, unresectable locally advanced or metastatic solid tumors of
• • UC, including MIBC
• • H\&N cancer
• • TNBC
• • Squamous NSCLC
• • Any other indication with confirmed carbonic anhydrase IX (CA IX) expression excluding ccRCC, PDAC and CRC, upon Sponsor agreement.
• Exclusion Criteria:
• • Any major surgery within 12 weeks before enrolment.
• • Inability to stay in the scanner bed with the arms resting out of the thoracic and abdominal fields (i.e., arms alongside the body or raised arm position) for the duration of the scan.
• Part A:
• • Has known hypersensitivity to the active substance, to any of the excipients of the DPI-4452, or to radiographic contrast agents.
• • Bladder outflow obstruction or unmanageable urinary incontinence.
• • Participants who have not had resolution of clinically significant toxic effects of prior systemic cancer therapy, surgery, or radiotherapy to Grade ≤1 (except for laboratory parameters specified above, Grade 2 alopecia, and/or stable Grade 2 sensory neuropathy, according to National Cancer Institute Common Terminology Criteria for Adverse Events \[NCI-CTCAE\]).
• • Administration of a radiopharmaceutical within a period corresponding to 10 half-lives of the radionuclide used prior to injection of \[68Ga\]Ga-DPI-4452.
• • Previous Carbonic anhydrase (CA) IX-targeting treatment.
• • Prior external beam radiation therapy (EBRT) to more than 25% of the bone marrow, as judged by the Investigator.
• Part B and Part C:
• • Known hypersensitivity to the active substance, to any of the excipients of the DPI-4452, or to radiographic contrast agents.
• • Bladder outflow obstruction or unmanageable urinary incontinence.
• • Participants who have not had resolution of clinically significant toxic effects of prior systemic cancer therapy, surgery, or radiotherapy to Grade ≤1 (except for laboratory parameters specified above, Grade 2 alopecia, or stable Grade 2 sensory neuropathy, according to NCI-CTCAE).
• • Administration of a radiopharmaceutical with therapeutic intent within a period of 6 months prior to injection of \[68Ga\]Ga-DPI-4452.
• • Any previous CA IX-targeting treatment for non-oncological indication within 3 months prior to the \[177Lu\]Lu-DPI-4452 infusion; any previous CA IX-targeting treatment for any oncological indication.
• • Participants who received any systemic antineoplastic therapy for the underlying disease and/or other investigational agents within a period which is ≤5 half-lives or ≤4 weeks (whichever is shorter).
• • Inflammatory bowel disease (e.g Crohn's disease, ulcerative colitis, etc).
• Part D:
• • Known hypersensitivity to the active substance, to any of the excipients of the DPI-4452, or to radiographic contrast agents.
• • Any previous CA IX-targeting treatment within 3 months prior to the \[68Ga\]Ga-DPI-4452 injection.
• • Administration of a radiopharmaceutical within a period corresponding to 10 half-lives of the radionuclide used prior to injection of \[68Ga\]Ga-DPI-4452.
• • Malignant disease, other than that being treated in this study. Exceptions include the following: malignancies that were treated curatively and have not recurred within 2 years prior to screening; treated basal cell or localized squamous skin carcinomas, localized or low grade (e.g., Gleason 3+3 or 3+4 with low prostate specific antigen) prostate cancer, superficial (non-muscle invasive) urothelial cancer, localized thyroid gland microcarcinoma, other in-situ carcinoma, or other malignancy for which participants are not on active antineoplastic therapy.
• • Ongoing treatment with sulfonamides and/or coumarin derivatives (e.g., acenocoumarol, warfarin, phenprocoumon) within 2 weeks (or 5 half-lives, whichever is longer) prior to the \[68Ga\]Ga-DPI-4452 injection.
• Part E:
• • Known hypersensitivity to the active substance, to any of the excipients of the DPI-4452, or to radiographic contrast agents.
• • Administration of a radiopharmaceutical within a period corresponding to 10 half-lives of the radionuclide used prior to injection of \[68Ga\]Ga-DPI-4452.
• • Any previous CA IX-targeting treatment within 3 months prior to \[68Ga\]Ga-DPI-4452 injection.
• • EBRT to more than 25% of the bone marrow, as judged by the Investigator.
• • Malignant disease, other than that being treated in this study. Exceptions include the following: malignancies that were treated curatively and have not recurred within 2 years prior to screening; treated basal cell or localized squamous skin carcinomas, localized or low grade (e.g., Gleason 3+3 or 3+4 with low prostate specific antigen) prostate cancer, superficial (non-muscle invasive) urothelial cancer, localized thyroid gland microcarcinoma, other in-situ carcinoma, or other malignancy for which participants are not on active antineoplastic therapy.
• • Note: Other inclusion/exclusion criteria mentioned in the protocol may apply.