Diagnostic Potential of the Salivary Biomarkers to Differentiate Statuses of Periodontitis

Launched by UNIVERSITY OF BAGHDAD · Feb 1, 2023

Keywords

ClinConnect Summary

Diagnosis of Periodontitis represents the backbone of a successful periodontal treatment since the entire treatment plan, prognosis, and maintenance directly depend on the quality and precision of periodontal diagnosis. Since periodontal diagnostics is still based on clinical and radiological parameters providing limited therapeutic guidance, biomarkers have been introduced for the first time within the new classification of periodontal and peri-implant conditions as a first step towards the adoption of precision medicine concepts in periodontology. Saliva, as part of oral fluids, is an opt...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male and female systemically healthy patients.
• • 2. Body mass index ≤ 30.
• • 3. Have a minimum of 20 teeth with facial and lingual scorable surfaces.
• 4. Clinical criteria for periodontal health and periodontitis will be as follows :
• • 1. Healthy periodontium (Group A): BOP \<10%, PPD ≤ 3mm, intact periodontium (no probing attachment loss).
• • 2. Periodontitis groups are defined as : i. Interdental CAL is detectable at ≥2 non-adjacent teeth, or ii. Buccal or oral CAL ≥3 mm with pocketing \>3mm is detectable at ≥2teeth
• Exclusion Criteria:
• • 1. Patients who refused to participate in the study.
• • 2. Individuals with dental implants.
• • 3. Previous history of extensive periodontal therapy preceding 6 months or currently under active periodontal treatment.
• • 4. Patients receiving antibiotic treatment or immunosuppressant medication within the last 3 months
• • 5. Pregnant or lactating mothers.
• • 6. Any symptoms of recent acute illness, e.g., COVID-19.
• • 7. Tobacco use.
• • 8. Active orthodontic therapy
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