Can Ultrasound be Used as a Measure of Muscle Quality? A Validation Study Comparing Ultrasound With MRI and MRS in Older and Younger Persons.

Launched by UNIVERSITY OF EXETER · Feb 6, 2023

Keywords

ClinConnect Summary

A key hallmark of the natural biology of ageing is a progressive loss of skeletal muscle mass, strength and aerobic capacity, termed 'sarcopenia' (Cruz-Jentoft et al. 2019a). The association between muscle loss (mass and quality) and increased incidence of falls, fractures, metabolic disease and other health complications is well established. Despite exercise and physiotherapy, recovery from these is often incomplete and studies have failed to identify fully effective countermeasures (Reeves et al, 2005). Ways to objectively measure the clinical effectiveness of the countermeasures are also...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Age \<40y or \>50yrs
• Exclusion Criteria:
• • 1. Significant cognitive deficits and the inability to follow directions during assessment.
• • 2. Neurological, neuromuscular, or musculoskeletal disorders that could impair the quality of the muscle. eg. CP, muscular dystrophy or SCI
• • 3. Prosthesis with metalwork, eg. metal work from surgery
• • 4. Aneurysm clip in situ
• • 5. No metal work anywhere, history of metal fragments in eyes, spinal cord or brain.
• • 6. Previous exposure to metal flakes and metallic injury.
• • 7. No external implants; cochlear implant, spinal cord simulator, pacemaker or other implanted electronic devices.
• • 8. Non-removal hearing aids
• • 9. FEMALE ONLY Not pregnant
• • 10. Not claustrophobic