Molecular Pathways of Cardiac Remodellation in Patients With Acute and Chronic Left Ventricular Disfunction

Launched by FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS · Feb 15, 2023

Keywords

ClinConnect Summary

The study will be interventional, prospective, and single-center. Partecipants will be divided into three groups:

1. 30 partecipants admitted to our hospital with the diagnosis of STEMI-type ACS and ejection fraction ≤ 35% on echocardiographic evaluation
2. 30 partecipants with non-ischaemic dilated cardiomyopathy and ejection fraction ≤35% on echocardiographic evaluation
3. 15 partecipants diagnosed with STEMI-type ACS and ejection fraction \> 50% on echocardiographic evaluation
4. 15 controls with normal left ventricular contractile function. The study foresees a phase of patient recruit...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients admitted to the Gemelli Polyclinic with acute coronary syndromes and heart disease;
• • patients admitted to our polyclinic with the diagnosis of SCA type STEMI and ejection fraction ≤ 35% at echocardiographic evaluation;
• • patients with non-ischemic dilated cardiomyopathy and ejection fraction ≤ 35% at echocardiographic evaluation;
• • patients diagnosed with SCA type STEMI and ejection fraction \> 50% at echocardiographic evaluation;
• Exclusion Criteria:
• • evidence of inflammatory or infectious disease;
• • malignancy, or immunological or hematologic disorders;
• • treatment with anti-inflammatory drugs other than low-dose aspirin;
• • age \> 85 years;
• • recent surgery (within one month);
• • advanced chronic kidney disease (eGFR MDRD-4 \<30 ml/min./1.73m2).