Carbetocin Compared To Oxytocin During Cesarean Delivery

Launched by ASSIUT UNIVERSITY · Mar 4, 2023

Keywords

ClinConnect Summary

Although the difference between carbetocin and oxytocin in terms of hemodynamic changes, postpartum blood loss and incidence of side effects is not statistically significant. serious cardiovascular adverse events, including ST segment depression, hypotension and tachycardia have been reported after IV oxytocin. Oxytocin dose reduction and/or increased infusion duration may reduce risk of some cardiac-related adverse effects and increase patient safety. As both oxytocin and carbetocin are used daily in obstetric units all over the world, the investigators find it compelling to investigate wh...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Normal singleton pregnancy at gestational age of 36 weeks or more.
• • Women with common comorbid diagnoses (diabetes, hypothyroidism, hypertension)
• • pregnancy after in vitro fertilization
• Exclusion Criteria:
• • placenta praevia or invasive placenta.
• • pre-eclampsia.
• • Bleeding disorder, such as von Willebrand disease type I.
• • Current treatment with low-molecular-weight heparin or other anticoagulation medication (not including aspirin).
• • Any known intolerance to either of the study drugs.
• • Prolonged QT-time.
• • Other serious cardiac disease.
• • Liver or kidney failure.