Treatment of Extracorporeal Membrane Oxygenation in Severe Poisoning

Launched by AFFILIATED HOSPITAL OF NANTONG UNIVERSITY · Feb 27, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how effective a special treatment called Extracorporeal Membrane Oxygenation (ECMO) is for patients who are critically ill due to poisoning. ECMO is a procedure that helps provide oxygen to the body when the heart and lungs are not working properly. The study will explore how different types of poisons and their doses affect the outcomes of patients receiving this treatment. By understanding this, doctors hope to improve how they use ECMO, including when and how to perform the procedure and whether to combine it with other treatments.

To be part of the trial, patients need to be experiencing severe poisoning that has led to life-threatening conditions like cardiac arrest (when the heart stops beating) or respiratory failure (when the lungs can't provide enough oxygen). Participants must not have other options available for treatment, and they should show signs that ECMO could help them. However, those with severe brain impairment, multiple organ failure, or serious bleeding issues will not be eligible. If someone qualifies and joins the study, they will receive close monitoring and care as part of the trial to see how well ECMO can help them recover.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Severe intoxication resulting in cardiac arrest, refractory malignant arrhythmia, refractory shock, refractory heart failure, respiratory failure.
• • Denying other available methods.
• • Indications for the use of the Extracorporeal membrane oxygenation exist.
• Exclusion Criteria:
• • Severely impaired state of consciousness prior to cardiac arrest;
• • Multiple organ dysfunction;
• • Uncontrolled traumatic bleeding, massive gastrointestinal bleeding, and active intracranial hemorrhage;
• • Left ventricular thrombosis; Severe aortic insufficiency.