Effect of Galacto-oligosaccharides (GOS) on Faecal Gut Microbiota in Adult Women

Launched by WAGENINGEN UNIVERSITY AND RESEARCH · Feb 27, 2023

Keywords

ClinConnect Summary

This randomized, parallel, double-blinded intervention study of 6 weeks will include 88 females, who will consume GOS for three consecutive weeks. Faecal samples will be collected at several time points to measure microbiota composition.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Apparently healthy women
• • Aged between 40 - 70 year
• • Body Mass Index (BMI) between 18.5 - 30 kg/m2
• Exclusion Criteria:
• • Having a gastro-intestinal disease, such as celiac disease, Crohn's disease, Ulcerative colitis, or diagnosed irritable bowel syndrome;
• • Having a history of intestinal surgery that might interfere with study outcomes. This does not include an appendectomy or cholecystectomy;
• • Diagnosed with diabetes mellitus;
• • Use of medication that may influence the study results, such as laxatives, lactase preparations, metformin, antibiotics, proton pomp inhibitors, antipsychotics, NSAID's (judged by our research physician);
• • Self-perceived and diagnosed constipation;
• • Having a food allergy to cow's milk or being lactose intolerant;
• • Self-reported slimming, medically prescribed or other diets
• • Reported weight loss or weight gain of \>5kg in the month prior to screening
• • Use of (foods with) pre-, pro-, syn- and/or postbiotics\* (should be stopped at least 4 weeks before the start of the study), or other supplements that can influence the study results (to be determined by the medical investigator);
• • History of side effects with the use of prebiotic supplements
• • Use of antibiotic treatment less than 3 months before start of the study
• • Pregnant or lactating (or having the wish to become pregnant during the study period, self-reported);
• • Not able to comply with study procedures;
• • Use of drugs (should be stopped at least 4 weeks before the study);
• • Alcohol intake ≥7 glasses of alcoholic beverages per week, on average
• • Participation in another clinical trial at the same time;
• • Being an employee of the Food, Health \& Consumer Research group of Wageningen Food \& Biobased Research or employee of FrieslandCampina R\&D.