Dietary Supplementation With Blueberry in OA

Launched by UNIVERSITY OF EXETER · Mar 13, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of blueberry supplementation on people with knee osteoarthritis, a painful condition that affects the joints and can lower quality of life. The researchers want to find out if eating blueberries can help reduce inflammation in the joints and improve symptoms, as well as potentially speed up recovery after knee replacement surgery. They will involve 58 adults over the age of 40 who are scheduled for knee replacement surgery. Participants will receive either blueberry supplements or a placebo (a non-active substance) for six weeks before and after their surgery.

To be eligible for this study, participants must be able to give informed consent and have a body mass index (BMI) over 18 kg/m². They should not have taken certain medications in the past two years or have other specific medical conditions that could affect the study's results. Participants can expect to provide tissue samples during their surgery and will be monitored for their joint symptoms and recovery process. This trial aims to provide valuable information about how blueberries might help manage osteoarthritis and improve recovery after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants capable of giving informed consent
• • Sex: Male and female
• • Age: \> 40 years - Those under 40 are more likely to have an undiagnosed secondary cause of osteoarthritis
• • BMI: \> 18 kg/m2
• • Listed to have a total knee replacement for osteoarthritis
• • Participants are permitted to participate in other ongoing surgical intervention studies, as long as these are not trials of a dietary supplement or a medication.
• Exclusion Criteria:
• • Those who have received intravenous or oral immunosuppressant medications in past 2 years
• • Those who have had intra-articular steroid injection in 6 months preceding surgery.
• * Some secondary causes of osteoarthritis (mechanistic confounders that are likely to influence tissue inflammation measures:
• • Known congenital joint disorders
• • Other inflammatory arthritis e.g. rheumatoid arthritis
• • Avascular necrosis, infectious arthritis
• • Paget disease
• • Osteopetrosis
• • Osteochondritis dissecans
• • Hemochromatosis
• • Wilson's disease
• • Hemoglobinopathy
• • Ehlers-Danlos syndrome
• • Marfan syndrome
• • Acromegaly
• • Those typically consuming more than eight 80 g portions (or juice equivalent) of blueberries, blackberries, strawberries, raspberries, blackcurrants, pomegranate or cherries per week
• • Those with a known fruit allergy, for which they carry an adrenaline auto-injector or have required anti-histamine, adrenaline, glucocorticoid or beta-agonist treatment.
• • Those who cannot adequately understand verbal explanations or written information given in English