Multicentric Prospective T1 Urinary Bladder Cancer Registry

Launched by MEDICAL UNIVERSITY OF VIENNA · Mar 17, 2023

Keywords

ClinConnect Summary

This clinical trial is studying patients with a specific type of bladder cancer known as T1 urinary bladder cancer. This type of cancer has a high chance of coming back after treatment, so the goal of the study is to gather detailed information about these patients to better understand their risk of recurrence and to improve treatment decisions. Researchers want to learn how various factors, like tumor size and type, affect outcomes and how accurately local doctors assess these tumors. By collecting data from around 700 patients, the study aims to create a reliable tool that doctors can use to guide their treatment recommendations.

To be eligible to participate, patients must have a confirmed diagnosis of T1 bladder cancer, which will be checked during a procedure called transurethral resection (TUR). They should not have any other significant health issues that would prevent surgery, and they need to agree to follow the standard care and follow-up plans. Participants in the trial will receive standard treatments based on their individual needs, and their health will be monitored regularly throughout the study. This research could lead to better management strategies for patients facing this challenging diagnosis.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• Subjects must meet all the following inclusion criteria to participate in this study:
• • Pathologically confirmed diagnosis of primary T1 bladder cancer
• • Diagnosis of primary T1 bladder cancer is confirmed at 2nd look TURB
• • Imaging examinations shows no lymph node metastasis or distant metastasis
• • Patients who agree to surgery, and will be effected to the standard postoperative management and follow-up treatment in accordance to current guidelines
• • In case of persistent T1 bladder cancer at 2nd look TURB, patient can be included only if detrusor muscle is present in the pathologic specimen
• • Exclusion criteria
• • Previous bladder cancer
• • Upstaging to MIBC at 2nd look TURB
• • Contraindications to surgery (i.e. bladder fibrosis)
• • Poor performance status making a surgical intervention too risky
• • Life expectancy of less than one year
• • Patient refused to participate
• • Pregnancy
• • Concomitant or history of upper urinary tract urothelial cancer