Small Sample，Unicentric，Randomized, Controlled Clinical Study of Coenzyme I for Injection in the Treatment of Sudden Sensorineural Hearing Loss

Launched by SUN YAT-SEN MEMORIAL HOSPITAL OF SUN YAT-SEN UNIVERSITY · May 8, 2023

Keywords

ClinConnect Summary

The recruited participants were patients with sudden hearing deafness, and the basic demographic data, including name, gender, age, medical history, etc., were collected. According to the inclusion and exclusion criteria, the patients were randomly divided into the experimental group and the control group. The experimental group was given conventional treatment + coenzyme I for injection, and the control group was given conventional treatment for 14 days. Baseline data were collected before treatment, and post-treatment data were collected on 3d, 7d, 14d，1m and 3m of treatment. Baseline dat...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18yrs.the 2019 American Sudden Deafness Guidelines are for patients with sudden deafness over 18 years of age;
• • 2. Patients diagnosed with sudden deafness, i.e. unexplained sensorineural hearing loss occurring within 72 hours, with hearing threshold ≥30 in at least 3 consecutive frequencies, refer to the 2019 American Sudden Deafness Guidelines;
• • 3. Unilateral sudden deafness;
• • 4. Within 1 week of the onset of sudden deafness, no treatment in another hospital/our hospital;
• • 5. No major neurological disease, serious systemic disease, family genetic history, major mental illness;
• • 6. Informed and agreed to join the experiment, no plan to move out or go out within 1 month.
• Exclusion Criteria:
• • 1. Other diseases such as acoustic neuroma diagnosed by imaging;
• • 2. Those who cannot tolerate NAD+;
• • 3. pregnant；
• • 4. Any other circumstances that the investigator believes should be excluded from this study；
• • 5. Do not agree to join the experiment, plan to move out or go out within 1 month.