Identification of Volatile Organic Compounds (VOCs) as Biopredictors of Epileptic Seizures

Launched by FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD · May 9, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the possibility of predicting epileptic seizures by identifying specific odors released by people with epilepsy. Researchers believe that these odors, known as volatile organic compounds (VOCs), can be detected up to three hours before a seizure occurs. By understanding these scents, the goal is to develop a reliable and non-invasive way to alert individuals with epilepsy about an impending seizure, which could help prevent accidents and improve their quality of life.

To participate in the trial, individuals must be at least 18 years old and have drug-resistant epilepsy, meaning their seizures don't respond well to medications. They should have a specific type of seizure, including focal seizures or generalized seizures, and need to undergo a video EEG test for at least 48 hours. Participants will work alongside researchers to help identify the odors associated with their seizures. It's important to note that pregnant or breastfeeding women and individuals under legal protection other than guardianship are not eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Person at least 18 years of age
• • With drug-resistant epilepsy according to the ILAE criteria
• * With one of the following 3 types of seizures :
• • Focal seizures Focal seizures with secondary generalization Generalized seizures - motor or non-motor
• • Requiring at least 48 hours of video-EEG
• • Consent to participate in the study from the patient and his/her legal guardian, if applicable
• • Affiliated or beneficiary of a social security plan
• Exclusion Criteria:
• • Person with epilepsy benefiting from a legal protection measure other than curatorship or guardianship
• • Pregnant or breastfeeding woman