MIND Diet to Improve Cognitive Function in Mild Stroke Patients

Launched by ZHEJIANG UNIVERSITY · Jun 17, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether the MIND Diet, which combines elements of the Mediterranean and DASH diets, can help improve thinking and memory in people who have had a mild stroke. The trial involves 60 participants aged 35 to 70 who are not diagnosed with dementia but are experiencing some cognitive changes after their stroke. The participants will follow the MIND Diet along with their usual medical care for six months to see if it makes a difference in their cognitive abilities and other health outcomes.

To be eligible for this study, participants must have experienced a mild stroke within the last two weeks and should score between 16-25 on a test that measures cognitive function. They also need to be able to eat a variety of foods, including nuts and fish, and not have any severe medical conditions or mental health issues. Throughout the study, participants will have regular check-ins to monitor their progress. It’s important to note that those who are pregnant, breastfeeding, or who have participated in other clinical trials in the past year cannot join. If you or a loved one is considering this trial, it could be a valuable opportunity to explore how diet may positively impact recovery after a stroke.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinically confirmed new cerebral infarction, onset hospitalization time ≤14 days
• • NHISS score of 0-6, with no difficulty in autonomous eating or aphasia
• • Baseline MMSE score being 16-25/30 points or MoCA score ≤24/30 points
• • Baseline MIND dietary pattern screening scale score ≤10/15 points
• • Body mass index no less than 18.0 kg/m2
• • Normal chewing function, able to eat hard foods such as nuts
• • Willing to participate and sign an informed consent form
• • Agree not to take over-the-counter nutritional supplements during the trial period
• • Able to understand research procedures and adhere to them throughout the entire study period
• • completed the run-in test
• Exclusion Criteria:
• • Diagnosis of dementia at a county-level or above hospital before the stroke or suspected to have pre-stroke dementia from the informant interview administered by a neurologist.
• • Participation in or have participated in other clinical trial studies within the past year
• • Allergies to foods involved in the experiment (nuts, berries, olive oil, or fish, etc.) or using drugs not compatible with foods involved.
• • Medication to treat Alzheimer's or Parkinson's disease
• • Diagnosis of cancer, severe liver and kidney disease, or current life expectancy less than 3 years
• • Diagnosis of depression, bipolar disorder, or other mental illnesses
• • Pregnancy or breastfeeding or with a pregnancy plan
• • Diagnosis of inflammatory bowel disease or other malabsorption-related gastrointestinal diseases
• • History of alcohol or drug abuse