Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD
Launched by ERASME UNIVERSITY HOSPITAL · Jun 23, 2023
Trial Information
Current as of May 25, 2025
Completed
Keywords
ClinConnect Summary
Slopes of He (SHe) and SF6 (SSF6) from single-breath washout test (SBWO) (assessing ventilation heterogeneities at the level of pre- and intra-acinar bronchioles, respectively) (quadruple model, LR6000 Logan-Sinclair, Rochester, UK), respiratory system resistance (R5, R5-R19) and reactance (X5, AX, Fres) from forced oscillation test (FOT) (Resmon Pro, ResTech, Italy), lung capillary volume (Vc) from double diffusion of NO and CO (DLNO/DLCO) (Hyp'Air compact, Medisoft, Dinant, Belgium), and FEV1 from spirometry (Zan®, Oberthulba, Germany) were evaluated before and after LABD administered via...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • COPD diagnosis according to international criteria
- Exclusion Criteria:
- • inability to perform the tests or to maintain the washout period
- • an exacerbation within the previous 6 weeks
- • a diagnosis of asthma or another chronic respiratory disease that could influence the results of the study
About Erasme University Hospital
Erasme University Hospital, a leading institution in clinical research and patient care, is dedicated to advancing medical knowledge and improving health outcomes through innovative clinical trials. As a prominent academic hospital affiliated with the Université libre de Bruxelles, it combines cutting-edge research with comprehensive clinical services, fostering collaboration among healthcare professionals, researchers, and patients. With a strong emphasis on rigorous scientific methodologies and ethical standards, Erasme University Hospital aims to contribute to the development of new therapies and treatment protocols that address pressing health challenges.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Brussels, , Belgium
Patients applied
Trial Officials
Silvia Pérez Bogerd, MD
Principal Investigator
Erasme University Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported