Evaluation of Prognostic Potentials of Gingival Crevicular Fluid E-cadherin and Total Antioxidant Capacity

Launched by ALI A ABDULKAREEM · Aug 9, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how certain substances in the mouth, specifically E-cadherin and total antioxidant capacity (TAC), can help predict the outcomes of treatment for gum disease, also known as periodontitis. By measuring these substances in the fluid found around the gums, researchers hope to better understand the severity of the disease and tailor treatment plans to improve results for patients.

To be eligible for this study, participants should be healthy adults over 18 who have been diagnosed with generalized periodontitis, which is characterized by specific gum issues that can cause tooth loss if not treated. Unfortunately, people who have recently taken antibiotics, are pregnant, smoke, or have certain health conditions like diabetes cannot participate. If you join the trial, you will help researchers gather important information that may lead to more effective ways to treat gum disease in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Systemically healthy adult patients (\> 18 years).
• • Periodontitis (interdental clinical attachment loss (CAL) detectable at ≥2 non-adjacent teeth, or buccal/oral CAL of ≥3mm with pocketing of \>3mm is detectable at ≥2 teeth). All patients should exhibit generalized periodontitis with pockets of PPD = 4 to 6 mm of any stage, unstable, and grade A to C. Only maxillary teeth with single root will be included.
• Exclusion Criteria:
• • Consumption of antibiotics or periodontal treatment 3-months prior to the study.
• • Pregnancy and lactation.
• • Smoker.
• • History of systemic disease e.g., diabetes mellitus.
• • Patients currently recruited in other trials.
• • Patients not willing to consent.
• • Periodontal pockets ≥ 7mm, active caries, endodontic problem.
• • Multi-rooted teeth will be also considered as exclusion reasons.