The Use of Platelet-rich-fibrin in Lower Third Molar Surgery.
Launched by AMERIGO GIUDICE · Dec 8, 2023
Trial Information
Current as of May 08, 2025
Completed
Keywords
ClinConnect Summary
The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial. Facial swelling will be assessed using an innovative three-dimensional digital technique.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients aged 18 to 32 years who required both M3M extractions were recruited
- • Good health status
- • Indication to surgical extraction of both M3M
- • Complete root formation
- • Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification
- Exclusion Criteria:
- • Person under the age of 18 or over 32
- • Allergy or contraindications to administration of corticosteroids
- • Acute infection in any of the teeth to be extracted
- • Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease
- • Pregnancy or breastfeeding
- • History of treatment with antiresorptive drugs
- • Chronic kidney disease
About Amerigo Giudice
Amerigo Giudice is a dedicated clinical trial sponsor committed to advancing medical research and improving patient outcomes through innovative studies. With a strong emphasis on ethical practices and regulatory compliance, the organization collaborates with leading researchers and institutions to conduct rigorous trials across various therapeutic areas. By fostering a culture of transparency and collaboration, Amerigo Giudice aims to accelerate the development of safe and effective treatments, ensuring that the needs of patients and the medical community are at the forefront of their initiatives.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Catanzaro, , Italy
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported